Journal article

Circulating steroid hormone concentrations in postmenopausal women in relation to body size and composition

Laura Baglietto, Dallas R English, John L Hopper, Robert J MacInnis, Howard A Morris, Wayne D Tilley, Kavitha Krishnan, Graham G Giles



Steroid hormones are associated with the risk of postmenopausal breast cancer and evidence suggests that increased concentrations of oestrogens from peripheral aromatisation in adipose tissue partly explains the association between body mass index (BMI) and risk of postmenopausal breast cancer. This study examined the associations between circulating concentrations of steroid hormones and anthropometric measurements in a sample of naturally postmenopausal women from the Melbourne Collaborative Cohort Study, not using hormone replacement therapy. We measured plasma concentration of total oestradiol, oestrone sulphate, dehydroepiandrosterone sulphate, androstenedione, testosterone and sex horm..

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Awarded by National Health and Medical Research Council

Awarded by NHMRC Sidney Sax Fellowship

Funding Acknowledgements

This study was made possible by the contribution of many people, including the original investigators and the diligent team who recruited the participants and who continue working on follow-up. We would like to express our gratitude to the many thousands of Melbourne residents who continue to participate in the study. We also acknowledge the contribution of Ms. Sonia Dunn for assistance with the hormone measurements. Cohort recruitment was funded by VicHealth and The Cancer Council Victoria. This study was funded by grants from the National Health and Medical Research Council (251533, 209057), and the National Breast Cancer Foundation, and was further supported by infrastructure provided by The Cancer Council Victoria. Dr. R. MacInnis is the recipient of a NHMRC Sidney Sax Fellowship (400470).