Assessing New Biomarkers and Predictive Models for Use in Clinical Practice A Clinician's Guide
Kevin McGeechan, Petra Macaskill, Les Irwig, Gerald Liew, Tien Y Wong
ARCHIVES OF INTERNAL MEDICINE | AMER MEDICAL ASSOC | Published : 2008
New biomarkers and predictive models that aim to improve the identification of people at risk of cardiovascular disease are constantly proposed. Clinicians need to be aware of the various methods used to assess these biomarkers and models and how these should be interpreted. New biomarkers and models are assessed in terms of their contribution to global fit, discrimination, calibration, and reclassification. These measures, when used in isolation, do not address the clinically important questions of whether the new model predicts risk more accurately than existing models and whether the risks predicted for individuals are sufficiently different to warrant a change in treatment decisions. We ..View full abstract
Awarded by Australian National Health and Medical Research Council Program
Funding/Support: The Screening and Test Evaluation Program is supported by the Australian National Health and Medical Research Council Program Grants ( No. 402764).