Journal article

Blinding Techniques in Randomized Controlled Trials of Laser Therapy: An Overview and Possible Solution

Ian Relf, Roberta Chow, Marie Pirotta

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | HINDAWI LTD | Published : 2008

Abstract

Low-level laser therapy has evidence accumulating about its effectiveness in a variety of medical conditions. We reviewed 51 double blind randomized controlled trials (RCTs) of laser treatment. Analysis revealed 58% of trials showed benefit of laser over placebo. However, less than 5% of the trials had addressed beam disguise or allocation concealment in the laser machines used. Many of the trials used blinding methods that rely on staff cooperation and are therefore open to interference or bias. This indicates significant deficiencies in laser trial methodology. We report the development and preliminary testing of a novel laser machine that can blind both patient and operator to treatment a..

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University of Melbourne Researchers