Journal article

Contribution of genes and environment to variation in postural changes in mean arterial and pulse pressure

Katrina J Scurrah, Sophie G Zaloumis, John L Hopper, Stephen B Harrap

JOURNAL OF HYPERTENSION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2008

Abstract

We have demonstrated that familial genetic and shared environmental factors influence postural responses of blood pressure, such that some families show a fall and others show a rise in systolic pressure on standing. These differences might reflect programmed differences in the underlying responses in mean arterial pressure and pulse pressure that together determine systolic pressure. Using variance components modelling techniques, we assessed familial aggregation of postural changes in mean arterial pressure and pulse pressure in 767 adult families from the Victorian Family Heart Study. On average mean arterial pressure rose (P < 0.001) and pulse pressure fell (P < 0.001) on standing, but t..

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Grants

Funding Acknowledgements

We thank Margaret Stebbing, the general practitioners and research nurses, and the Australian Twin Registry and Professor Graham G. Giles and the Health 2000 Study for their contributions to participant recruitment. This work was supported by the Victorian Health Promotion Foundation and the National Health and Medical Research Council of Australia.