Does performance on the standard antisaccade task meet the co-familiality criterion for an endophenotype?
Deborah L Levy, Elizabeth A Bowman, Larry Abel, Olga Krastoshevsky, Verena Krause, Nancy R Mendell
BRAIN AND COGNITION | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2008
The "co-familiality" criterion for an endophenotype has two requirements: (1) clinically unaffected relatives as a group should show both a shift in mean performance and an increase in variance compared with controls; (2) performance scores should be heritable. Performance on the antisaccade task is one of several candidate endophenotypes for schizophrenia. In this paper we examine whether the various measures of performance on the standard version of the antisaccade task meet the co-familiality criterion for an endophenotype. The three measures of performance-reflexive saccade errors, latency of correct antisaccades, and gain-show a wide range of effect sizes and variance ratios as well as ..View full abstract
Awarded by NIMH
Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH
This study was supported in part by NIMH Grants R01 MH071523 and MH31340, the Sidney R. Baer Jr. Foundation, the Essel Foundation, and the National Association for Research on Schizophrenia and Depression. The authors thank Dr. Mark Lenzenweger for critical comments and helpful discussion.