Journal article

Twins discordant for schizophrenia: psychopathology of the non-schizophrenic co-twins

SV Argyropoulos, S Landau, S Kalidindi, T Toulopoulou, DJ Castle, RM Murray, MM Picchioni

ACTA PSYCHIATRICA SCANDINAVICA | WILEY-BLACKWELL | Published : 2008

Abstract

OBJECTIVE: Patients with schizophrenia are more likely to suffer from mood and anxiety disorders compared with the general population. We explored the aetiology of this comorbidity using a twin study design. METHOD: We applied an additive genetic + unique environment (AE) random effects model in the analysis of 35 non-schizophrenic co-twins from pairs discordant for schizophrenia, and 131 control twins. RESULTS: Non-schizophrenic co-twins had significantly increased rates of depression (P = 0.006) and anxiety disorders (P = 0.021) compared with the control twins. CONCLUSION: Our results provide evidence for a familial association between schizophrenia and anxiety and depression. This could r..

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