Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion
Connie HY Wong, Steven Bozinovski, Paul J Hertzog, Michael J Hickey, Peter J Crack
Journal of Neurochemistry | WILEY | Published : 2008
Mice deficient in the anti-oxidant enzyme glutathione peroxidase-1 (Gpx1) have a greater susceptibility to cerebral injury following a localized ischemic event. Much of the response to ischemia-reperfusion is caused by aberrant responses within the microvasculature, including inflammation, diminished endothelial barrier function (increased vascular permeability), endothelial activation, and reduced microvascular perfusion. However, the role of Gpx1 in regulating these responses has not been investigated. Wild-type and Gpx1-/- mice underwent focal cerebral ischemia via mid-cerebral artery occlusion followed by measurement of cerebral perfusion via laser Doppler and intravital microscopy. Post..View full abstract
Awarded by National Health and Medical Research Council (NHMRC), Australia
These studies were supported by a Program Grant from the National Health and Medical Research Council (NHMRC), Australia (ID # 334067). PJH is an NHMRC Senior Principal Research Fellow. MJH is an NHMRC Senior Research Fellow.