Possible Effects of Microbial Ecto-Nucleoside Triphosphate Diphosphohydrolases on Host-Pathogen Interactions
Fiona M Sansom, Simon C Robson, Elizabeth L Hartland
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | AMER SOC MICROBIOLOGY | Published : 2008
In humans, purinergic signaling plays an important role in the modulation of immune responses through specific receptors that recognize nucleoside tri- and diphosphates as signaling molecules. Ecto-nucleoside triphosphate diphosphohydrolases (ecto-NTPDases) have important roles in the regulation of purinergic signaling by controlling levels of extracellular nucleotides. This process is key to pathophysiological protective responses such as hemostasis and inflammation. Ecto-NTPDases are found in all higher eukaryotes, and recently it has become apparent that a number of important parasitic pathogens of humans express surface-located NTPDases that have been linked to virulence. For those paras..View full abstract
Awarded by NIH
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
This work was supported by Australian National Health and Medical Research Council (NHMRC) grants awarded to E.L.H. and by NIH grants (HL57307, HL63972, and HL076540) to S.C.R.