Journal article

The Natural History of Serum Iron Indices for HFE C282Y Homozygosity Associated With Hereditary Hemochromatosis

Lyle C Gurrin, Nicholas J Osborne, Clare C Constantine, Christine E McLaren, Dallas R English, Dorota M Gertig, Martin B Delatycki, Melissa C Southey, John L Hopper, Graham G Giles, Gregory J Anderson, John K Olynyk, Laurie W Powell, Katrina J Allen

GASTROENTEROLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 2008

Abstract

BACKGROUND & AIMS: There are few longitudinal studies of serum ferritin (SF) and transferrin saturation (TS) levels in individuals homozygous for the C282Y mutation. We characterized the development of elevated iron measures in C282Y homozygotes followed for 12 years. METHODS: From 31,192 people aged 40-69 years at baseline, we identified 203 C282Y homozygotes (95 males), of whom 116 had SF and fasting TS levels measured at baseline (mean age, 55 years) and 86 were untreated and had iron measures at follow-up (mean, 12 years later). The probabilities of SF at follow-up exceeding clinical thresholds were predicted from baseline SF and TS under a multivariate normal model. RESULTS: For C282Y h..

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Grants

Awarded by National Institute of Diabetes, Digestive and Kidney Diseases


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

Supported by the National Institute of Diabetes, Digestive and Kidney Diseases (US) (1 R01 DK061885-01 A2); National Health and Medical Research Council (NHMRC) (Australia) (project grant number 251668); by VicHealth and The Cancer Council Victoria for cohort recruitment; The Cancer Council Victoria and the NHMRC (program grant 209057, enabling grant 396414) for continuing follow-up; and by NHMRC Career Development Award (to L.C.G. and K.J.A), NHMRC Practitioner Fellowship (to M.B.D. and J.K.O), NHMRC Senior Research Fellowship (to M.C.S and G.J.A.), and NHMRC Australia Fellowship (to J.L.H.).