Enantioselective preparation of a stable boronate complex stereogenic only at boron

Abstract

Asymmetric synthesis of a boronate complex stereogenic exclusively at boron has been achieved through chirality transfer from a carbon stereocenter that is subsequently abolished. The boronate complex is formed with >99% ee and is remarkably configurationally stable, with no racemization observed after 24 h at 110°. Copyright © 2008 American Chemical Society.