High Incidence of Hepatitis C Virus Reinfection in a Cohort of Injecting Drug Users
Campbell Kynoch Aitken, Jennifer Lewis, Samantha Lilly Tracy, Timothy Spelman, David Scott Bowden, Mandvi Bharadwaj, Heidi Drummer, Margaret Hetlard
HEPATOLOGY | WILEY-BLACKWELL | Published : 2008
UNLABELLED: An estimated 170 million people worldwide carry the hepatitis C virus (HCV), and in more developed countries the prevalence and incidence of HCV is particularly high among injecting drug users (IDUs). Spontaneous clearance of HCV infection and reinfection is well recognized but the level of protection against further infection conferred by HCV infection and clearance remains uncertain. We conducted a prospective study of HCV infection in IDUs recruited in Melbourne, Australia, using a much shorter median testing interval than in previous studies. Incidences of naive infection and reinfection were calculated by the person-year method and Cox proportional hazards regression used to..View full abstract
Awarded by Australia National Health and Medical Research Council (NHMRC)
Supported by VicHealth grant to M.H., and by Australia National Health and Medical Research Council (NHMRC) Project #331312 to M. H.