Journal article

Multiple loci with different cancer specificities within the 8q24 gene desert

Maya Ghoussaini, Honglin Song, Thibaud Koessler, Ali Amin Al Olama, Zsofia Kote-Jarai, Kristy E Driver, Karen A Pooley, Susan J Ramus, Susanne Krueger Kjaer, Estrid Hogdall, Richard A DiCioccio, Alice S Whittemore, Simon A Gayther, Graham G Giles, Michelle Guy, Stephen M Edwards, Jonathan Morrison, Jenny L Donovan, Freddie C Hamdy, David P Dearnaley Show all

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | OXFORD UNIV PRESS INC | Published : 2008

Abstract

Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with susceptibility to breast, prostate, and colorectal cancer. This locus lies within a 1.18-Mb region that contains no known genes but is bounded at its centromeric end by FAM84B and at its telomeric end by c-MYC, two candidate cancer susceptibility genes. To investigate the associations of specific loci within 8q24 with specific cancers, we genotyped the nine previously reported cancer-associated single-nucleotide polymorphisms across the region in four case-control sets of prostate (1854 case subjects and 1894 control subjects), breast (2270..

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