Early onset of ghrelin production in a marsupial
Brandon R Menzies, Geoff Shaw, Terry P Fletcher, Marilyn B Renfree
MOLECULAR AND CELLULAR ENDOCRINOLOGY | ELSEVIER IRELAND LTD | Published : 2009
Ghrelin regulates appetite in mammals and can stimulate growth hormone (GH) release from the pituitary. In rats and humans, ghrelin cells appear in the stomach during late fetal life. Nevertheless, the role of ghrelin in early mammalian development is not well understood. Marsupials deliver highly altricial young that weigh less than 1g so they must feed and digest milk at a comparatively immature stage of development. Since they complete their growth and differentiation while in the pouch, they are accessible models in which to determine the time course of ghrelin production during development. We examined the distribution of gastric ghrelin cells, plasma ghrelin concentrations and pituitar..View full abstract
We thank Dr. Andrew Pask and Ms. Helen Gehring for advice and assistance with molecular aspects of the study and to Dr. Danielle Hickford for assistance with the immunohistochemistry. This work was supported by a Loftus-Hills Memorial grant to BRM and a Federation Fellowship to MBR.