Aurora kinase B is an independent protective factor in superficial bladder tumours with a dysfunctional G1 checkpoint

Abstract

OBJECTIVES: To investigate the clinical role of Aurora kinases (essential for regulating mitosis) in human bladder pathogenesis, by quantifying Aurora kinase A and B, phospho-Aurora A, and phospho-Rb and p53 in bladder tumours, analysing the correlations between expression and clinicopathological features. PATIENTS AND METHODS: We evaluated levels of Aurora A, B, phospho-Aurora A, phospho-Rb and p53 in 73 superficial bladder tumours using tissue microarrays and immunohistochemistry, and correlated expression with pathological variables and clinical outcome. RESULTS: None of the Aurora proteins, when analysed alone, significantly predicted either tumour recurrence or progression. In tumours w..