Journal article

Voxel-Based Iterative Sensitivity (VBIS) analysis: Methods and a validation of intensity scaling for T2-weighted imaging of hippocampal sclerosis

David F Abbott, Gaby S Pell, Heath Pardoe, Graeme D Jackson

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2009

Abstract

Abnormalities in the brain generally manifest on MRI as changes in shape (morphometry) or changes in the nature of the tissue (signal intensity). Voxel Based Morphometry (VBM) is a whole brain quantitative way of assessing morphometric changes. Voxel Based Relaxometry (VBR) directly assesses signal intensity changes in quantitative maps of T2 relaxation time, but this requires specialised multiple-echo acquisition sequences that are not usually available at clinical sites. This paper introduces and assesses an objective voxel-based statistical method for evaluation of signal intensity in groups of routinely acquired qualitative images. We call the method Voxel-Based Iterative Sensitivity (VB..

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