Multi-site voxel-based morphometry: Methods and a feasibility demonstration with childhood absence epilepsy

Heath Pardoe; Gaby S Pell; David F Abbott; Anne T Berg; Graerne D Jackson

Journal article

Multi-site voxel-based morphometry: Methods and a feasibility demonstration with childhood absence epilepsy

Heath Pardoe, Gaby S Pell, David F Abbott, Anne T Berg, Graerne D Jackson

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2008

DOI: 10.1016/j.neuroimage.2008.05.007

Abstract

AIM: Voxel-based morphometry analysis of neurological disorders would benefit if it could use data acquired from different scanners, but scanner based contrast variation could interfere with the detection of disease-specific structural abnormalities. In this study we examine MRI data from three different sites to investigate structural differences between childhood absence epilepsy (CAE) subjects and controls. METHODS: T1-weighted structural MRI scans were acquired from: Site A. 10 CAE, 213 controls; Site B. 15 CAE, 33 controls; and Site C. 19 CAE, 11 controls. The images were processed using the optimised VBM protocol. Three statistical analyses were undertaken: (1) Comparisons of CAE subje..

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University of Melbourne Researchers

David Abbott Author Medicine - Austin Health

Graeme Jackson Author Florey Department of Neuroscience and Mental Health

Related Projects (1)

Epilepsy: Molecular basis and mechanisms in the era of functional genomics

The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain..

Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia

Awarded by NIH-NINDS, USA

Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

Funding Acknowledgements

This publication was supported by Program Grant 400121 from the National Health and Medical Research Council (NH&MRC), Australia, and Grant R37NS31146 (June 1, 2007 May 31, 2011) from NIH-NINDS, USA. The authors wish to acknowledge helpful contributions from the UCL Institute of Child Health, London, UK. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the NH&MRC, NIH-NINDS or the UCL Institute of Child Health.