Journal article

Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair

Mark P Marriott, Ben Emery, Holly S Cate, Michele D Binder, Dennis Kemper, Qizhu Wu, Scott Kolbe, Ian R Gordon, Hong Wang, Gary Egan, Simon Murray, Helmut Butzkueven, Trevor J Kilpatrick

Glia | WILEY-LISS | Published : 2008

Abstract

Leukemia inhibitory factor (LIF) receptor signaling limits the severity of inflammatory demyelination in experimental autoimmune encephalomyelitis, a T-cell dependent animal model of multiple sclerosis (MS) [Butzkueven et al. (2002) Nat Med 8:613-619]. To identify whether LIF exerts direct effects within the central nervous system to limit demyelination, we have studied the influence of LIF upon the phenotype of mice challenged with cuprizone, a copper chelator, which produces a toxic oligodendrocytopathy. We find that exogenously administered LIF limits cuprizone-induced demyelination. Knockout mice deficient in LIF exhibit both potentiated demyelination and oligodendrocyte loss after cupri..

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