Early undernutrition leads to long-lasting reductions in body weight and adiposity whereas increased intake increases cardiac fibrosis in male rats
Elena Velkoska, Timothy J Cole, Rachael G Dean, Louise M Burrell, Margaret J Morris
JOURNAL OF NUTRITION | AMER SOC NUTRITIONAL SCIENCE | Published : 2008
Previous studies suggest that both overfeeding and undernutrition during development increase the risk of obesity and hypertension in adulthood. In this study, we examined both short- (24 d) and long- (16 wk) term effects of early postnatal over- and underfeeding in rats on body weight, body composition, plasma hormones, adiposity markers, and hypothalamic neuropeptide Y content. Cardiovascular changes were also examined by measuring blood pressure and cardiac fibrosis. Rats raised in litters of 3, 12, or 18 pups per mother were used to model early onset overfeeding, control, and underfeeding, respectively. At 24 d of age, pups raised in small litters (SL) were 10% heavier than pups from nor..View full abstract
Supported by the National Health and Medical Research Council-Australia E V. was supported by a Postgraduate Scholarship from the National Heart Foundation of Australia.