Journal article

Lung parenchyma at maturity is influenced by postnatal growth but not by moderate preterm birth in sheep

Gert Maritz, Megan Probyn, Robert De Matteo, Ken Snibson, Richard Harding

NEONATOLOGY | KARGER | Published : 2008


BACKGROUND: We have recently shown that moderate preterm birth, in the absence of respiratory support, altered the structure of lung parenchyma in young lambs, but the long-term effects are unknown. OBJECTIVES: To determine whether structural changes persist to maturity, and whether postnatal growth affects lung structure at maturity in sheep. METHODS: At approximately 1.2 years after birth, lung parenchyma of sheep born 14 days before term (n = 7) was stereologically compared with that of controls born at term (n = 8, term approx. 146 days). RESULTS: Preterm birth per se had no significant effect on lung volume, alveolar number and size, and thicknesses of the alveolar walls and blood-gas b..

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University of Melbourne Researchers