Journal article

Copper binding to the Alzheimer's disease amyloid precursor protein

Geoffrey K-W Kong, Luke A Miles, Gabriela AN Crespi, Craig J Morton, Hooi Ling Ng, Kevin J Barnham, William J McKinstry, Roberto Cappai, Michael W Parker

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | SPRINGER | Published : 2008

Abstract

Alzheimer's disease is the fourth biggest killer in developed countries. Amyloid precursor protein (APP) plays a central role in the development of the disease, through the generation of a peptide called A beta by proteolysis of the precursor protein. APP can function as a metalloprotein and modulate copper transport via its extracellular copper binding domain (CuBD). Copper binding to this domain has been shown to reduce A beta levels and hence a molecular understanding of the interaction between metal and protein could lead to the development of novel therapeutics to treat the disease. We have recently determined the three-dimensional structures of apo and copper bound forms of CuBD. The s..

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