Surgical access to the mammalian cochlea for cell-based therapies
Steven Backhouse, Bryony Coleman, Robert Shepherd
EXPERIMENTAL NEUROLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2008
Cochlear implants are dependent on functionally viable spiral ganglion neurons (SGNs) - the primary auditory neurons of the inner ear. Cell-based therapies are being used experimentally in an attempt to rescue SGNs from deafness-induced degeneration or to generate new neurons. The success of these therapies will be dependent on the development of surgical techniques designed to ensure precise cell placement while minimizing surgical trauma, adverse tissue reaction and cell dispersal. Using 24 normal adult guinea pigs we assessed three surgical procedures for cell delivery into the cochlea: (i) a cochleostomy into the scala tympani (ST); (ii) direct access to Rosenthal's canal - the site of t..View full abstract
Awarded by National Institutes of Health (NIDCD)
We are grateful to the following individuals for their contributions to this work: Ms J. Andrew, Ms L. Donnelly, Ms P. Nielsen, Dr S. Pierce and Ms E. Borg. This work was funded by The Thomas Wickham Jones Foundation, The Royal Victorian Eye and Ear Hospital, the National Institutes of Health (NIDCD N01-DC-3-1005 and HHS-N-263-2007-00053-C), the Department of Otolaryngology, University of Melbourne and the Bionic Ear Institute.