Journal article

Intracellular copper deficiency increases amyloid-ss secretion by diverse mechanisms

Michael A Cater, Kelly T McInnes, Qiao-Xin Li, Irene Volitakis, Sharon La Fontaine, Julian FB Mercer, Ashley I Bush

Biochemical Journal | PORTLAND PRESS LTD | Published : 2008

DOI: 10.1042/BJ20080103

University of Melbourne Researchers

Qiao-Xin Li Author Melbourne Medical School

Ashley Bush Author Florey Department of Neuroscience and Mental Health

Related Projects (1)

THE ROLE OF AMYLOID PROTEIN PRECURSOR IN MAMMALIAN COPPER TRANSPORT

The knowledge gained from this investigation will help us to develop new medicines for the treatment of debilitating and ever more prevalent..

Grants

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Keywords

Amyloid Beta-Protein Precursor

Sequence Homology, Amino Acid

Menkes Protein (atp7a)

Biochemistry & Molecular Biology

Science & Technology

Protein Biosynthesis

Transcription, Genetic

Transgenic Mice

Alzheimer'S Disease (ad)

Amyloid Precursor Protein (app)

Intracellular Fluid

Signal Transduction

Amyloid Precursor Protein Secretases

Alzheimers-Disease

Oxidative Stress

Amino Acid Sequence

Precursor-Protein

Cells, Cultured

Life Sciences & Biomedicine

Amyloid Beta-Peptides

Protein Processing, Post-Translational

Gene Expression Regulation

Nerve Tissue Proteins

Molecular Sequence Data

Hippocampal-Neurons