Going up in smoke: Tobacco smoking is associated with worse treatment outcomes in mania

Abstract

Background: This study aimed to compare the treatment responses between smokers and non-smokers in bipolar mania clinical trials. Methods: Post-hoc analysis was conducted on data collected from three double-blind, randomised controlled trials in bipolar mania that had similar inclusion criteria. Patients were randomised to olanzapine (N = 70) or placebo (N = 69) for 3 weeks in Trial 1, olanzapine (N = 234) or haloperidol (N = 216) for 12 weeks in Trial 2, and olanzapine (N = 125) or divalproex (N = 126) for 47 weeks in Trial 3. This study analysed the Young Mania Rating Scale (YMRS) total scores and Clinical Global Impressions scale for bipolar disorder (CGI-BP) mania severity scores between..