Journal article
Novel measures of cardiovascular health and its association with prevalence and progression of age-related macular degeneration: The CHARM study
CA McCarty, A Dowrick, J Cameron, B McGrath, LD Robman, P Dimitrov, G Tikellis, C Nicolas, J McNeil, R Guymer
BMC Ophthalmology | BMC | Published : 2008
Abstract
Background. To determine if novel measures of cardiovascular health are associated with prevalence or progression of age-related macular degeneration (AMD). Methods. Measures of the cardiovascular system: included intima media thickness (IMT), pulse wave velocity (PWV), systemic arterial compliance (SAC), carotid augmentation index (AI). For the prevalence study, hospital-based AMD cases and population-based age- and gender-matched controls with no signs of AMD in either eye were enrolled. For the progression component, participants with early AMD were recruited from two previous studies; cases were defined as progression in one or both eyes and controls were defined as no progression in eit..
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Funding Acknowledgements
The CHARM Study was funded in large part by project grant number 128201 from the National Health and Medical Research Council. Support was also received from the Ramaciotti Foundation, the Hugh D. Williamson Foundation, and the Lions Clubs of Victoria. The authors acknowledge the contributions of Sonya Ristevski to training and ongoing quality assurance for the arterial structure measurements.