Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect?
LJ Prior, E Velkoska, R Watts, D Cameron-Smith, MJ Morris
INTERNATIONAL JOURNAL OF OBESITY | NATURE PUBLISHING GROUP | Published : 2008
OBJECTIVE: Nutrition during critical periods in early life may increase the subsequent risk of obesity, hypertension and metabolic diseases in adulthood. Few studies have focused on the long-term consequences of poor nutrition during the suckling period on the susceptibility to developing obesity when exposed to a palatable cafeteria-style high-fat diet (CD) after weaning. DESIGN: This study examined the impact of early undernutrition, followed by CD exposure, on blood pressure, hormones and genes important for insulin sensitivity and metabolism and skeletal muscle mRNA expression of adiponectin receptor 1 (AdipoR1), carnitine palmitoyl-transferase I (CPT-1), cytochrome c oxidase 4 (COX4) an..View full abstract
This work was supported by the Janet Bryson Memorial Scholarship from the Australasian Society for the Study of Obesity and a Project Grant from National Health and Medical Research Council of Australia to M Morris.