Journal article
A functional MRI study of Theory of Mind in euthymic bipolar disorder patients
GS Malhi, J Lagopoulos, P Das, K Moss, M Berk, CM Coulston
Bipolar Disorders | WILEY | Published : 2008
Abstract
Objectives: To determine the neural responses invoked in Theory of Mind (ToM) in euthymic bipolar patients as compared with healthy subjects. Methods: This study examined 20 euthymic bipolar patients (11 males and 9 females) and 20 suitably matched healthy subjects using functional magnetic resonance imaging (fMRI) while subjects were engaged in a ToM task. Within-scanner eye movements were monitored to ensure task engagement. The activation paradigm involved observing ToM and random-motion animated sequences in a block design. Both within group (ToM versus random motion) and random effects between group analyses were performed on fMRI data using the BrainVoyager software package. Demographi..
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Awarded by NHMRC Program
Funding Acknowledgements
The authors acknowledge the Australian Rotary Health Research Fund and the NHMRC Program Grant (510135) for essential financial support and the University of Sydney Northern Clinical School Advanced Research Clinical High-field Imaging (ARCHI) Facility at Royal North Shore Hospital for the necessary infrastructure. The authors acknowledge Mrs. Belinda Ivanovski for assistance with subject recruitment and also kindly thank Mrs. Vicki Campbell and Ms. Mannat Malhi for their assistance in the preparation of this manuscript.