Journal article
Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet
LR Guimarães, FN Jacka, CS Gama, M Berk, CL Leitão-Azevedo, MG Belmonte de Abreu, MI Lobato, AC Andreazza, KM Ceresér, F Kapczinski, P Belmonte-de-Abreu
Progress in Neuro Psychopharmacology and Biological Psychiatry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2008
Abstract
Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one on a hypocaloric diet (HD) and the other not on a hypocaloric diet. Weight, height and BMI data were collected concurrently with 5-ml blood sampling of each subject. BDNF levels were measured with a sandwich-ELISA. The blood sample was obtained a minimum of one month after the exposure to dietary intervention. Serum BDNF levels were significantly higher in patients on the HD (p = 0.023). Additiona..
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Awarded by Conselho Nacional de Desenvolvimento Científico e Tecnológico
Funding Acknowledgements
Clarissa Severino Gama is funded by CNPq (PDE #200310/2007-0). Brazil; and Endeavour Awards Programme (#539/2008), Australia.