Journal article

The in vitro anticoagulant effects of Danaparoid, Fondaparinux, and Lepirudin in children compared to adults

Vera Ignjatovic, Robyn Surnmerhayes, Yan Yan Yip, Paul Monagle



INTRODUCTION: Major physiological differences in the coagulation system of children compared to that of adults are well documented. We have previously investigated the age-related differences in response to Unfractionated Heparin (UFH). However, the impact of developmental haemostasis on more recent anticoagulant drugs is unknown. A number of these drugs are approved for use in specific indications in adults and none are approved for use in children. This study aimed to determine whether age-related differences in effect and impact on monitoring tests exist in vitro for danaparoid, fondaparinux and lepirudin. MATERIALS AND METHODS: Plasma samples were obtained from healthy children and poole..

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Funding Acknowledgements

The authors acknowledge assistance of the members of Anaesthetic, Surgical and Dermatology departments of the Royal Children's Hospital (RCH), Melbourne, for facilitation of sample collection. The support of the RCH Core Laboratory staff in handling specimens is also acknowledged Dr Ignjatovic is supported by the Sanofi-Aventis Clinical Research Fellowship.