Journal article

Postnatal growth rate, but not mild preterm birth, influences airway structure in adult sheep challenged with house dust mite

Ken Snibson, Richard Harding

EXPERIMENTAL LUNG RESEARCH | TAYLOR & FRANCIS INC | Published : 2008

Abstract

The authors recently showed that preterm birth per se, in the absence of assisted ventilation or elevated inhaled oxygen levels, alters the structure of the airway walls in young lambs. The initial aim of the present study was to determine whether these changes persist into adulthood. Preterm (P; n = 7) lambs were delivered 14 days before term and compared with control lambs (C; n = 8) born at term ( approximately 147 days). After weaning, the sheep were kept as a flock with daily exposure to pasture until approximately 1.2 years old. All sheep were sensitized to house dust mite extract and then given aerosol challenges with house dust mite 10 to 12 weeks before autopsy. At autopsy, the righ..

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University of Melbourne Researchers