Tv-RIO1-an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus
Min Hu, Nicole LaRonde-LeBlanc, Paul W Sternberg, Robin B Gasser
PARASITES & VECTORS | BMC | Published : 2008
UNLABELLED: BACKGROUND: Protein kinases are key enzymes that regulate a wide range of cellular processes, including cell-cycle progression, transcription, DNA replication and metabolic functions. These enzymes catalyse the transfer of phosphates to serine, threonine and tyrosine residues, thus playing functional roles in reversible protein phosphorylation. There are two main groups, namely eukaryotic protein kinases (ePKs) and atypical protein kinases (aPKs); RIO kinases belong to the latter group. While there is some information about RIO kinases and their roles in animals, nothing is known about them in parasites. This is the first study to characterise a RIO1 kinase from any parasite. RE..View full abstract
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Awarded by Australian Research Council
This work was supported by the Australian Research Council (LP0667795 and LX0882231), Genetic Technologies Limited, Meat and Livestock Australia, the Australian Academy of Science, the Australian-American Fulbright Commission (RBG), and the Howard Hughes Medical Institute (PWS).