Impact of glycans on T-cell tolerance to glycosylated self-antigens
Anthony W Purcell, Ian R van Driel, Paul A Gleeson
IMMUNOLOGY AND CELL BIOLOGY | WILEY | Published : 2008
There is now substantial evidence that antigen post-translational modifications are recognized by T cells, and alterations in epitope modification has been linked to a number of autoimmune diseases. An estimated one third of the MHC ligands contain post-translational modification of epitopes. A common post-translational modification of proteins is glycosylation and it is predicted on theoretical grounds that approximately 1-5% of MHC ligands may bear a glycan. From numerous studies over the past 15 years it is clear that glycans can influence T cell responses either by contribution to the structure of the epitope or by influencing the profile of peptide epitopes presented by APCs. The influe..View full abstract
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Awarded by Australian National Health and Medical Research Council, Australia
This work was supported by Australian National Health and Medical Research Council, Australia, project Grants 400219 to IVD and PAG and 508927 to AWP and a Senior Research Fellowship to AWP.