Journal article
Sox18 induces development of the lymphatic vasculature in mice
M François, A Caprini, B Hosking, F Orsenigo, D Wilhelm, C Browne, K Paavonen, T Karnezis, R Shayan, M Downes, T Davidson, D Tutt, KSE Cheah, SA Stacker, GEO Muscat, MG Achen, E Dejana, P Koopman
Nature | NATURE PUBLISHING GROUP | Published : 2008
DOI: 10.1038/nature07391
Abstract
The lymphatic system plays a key role in tissue fluid regulation and tumour metastasis, and lymphatic defects underlie many pathological states including lymphoedema, lymphangiectasia, lymphangioma and lymphatic dysplasia. However, the origins of the lymphatic system in the embryo, and the mechanisms that direct growth of the network of lymphatic vessels, remain unclear. Lymphatic vessels are thought to arise from endothelial precursor cells budding from the cardinal vein under the influence of the lymphatic hallmark gene Prox1 (prospero homeobox 1; ref. 4). Defects in the transcription factor gene SOX18 (SRY (sex determining region Y) box 18) cause lymphatic dysfunction in the human syndrom..
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Awarded by Pfizer Foundation
Funding Acknowledgements
We thank A. Nagy, W. Abramow-Newerly, L. Naldini, P. Berta, A. Yap and J. Gamble for gifts of reagents. We also thank L. Bernard, L. Tizzoni and V. Dall'Olio for quantitative real- time PCR analysis, M. Chan and A. Pelling for antibody characterization, and S. Pizzi for technical assistance. Confocal microscopy was performed at the Australian Cancer Research Foundation Dynamic Imaging Centre for Cancer Biology. This work was supported by the National Health and Medical Research Council ( Australia), INSERM ( France), the Associazione Italiana per la Ricerca sul Cancro ( Italy), the European Community (LSHG-CT-2004-503573, Eustroke and Optistem networks), the Pfizer Foundation (Australia), the Research Grants Council (Hong Kong), the Raelene Boyle Sporting Chance Foundation ( Australia), the Royal Australasian College of Surgeons, the Heart Foundation of Australia, and the Australian Research Council.