Low-Fouling, Biofunctionalized, and Biodegradable Click Capsules
Christopher J Ochs, Georgina K Such, Brigitte Staedler, Frank Caruso
BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2008
We report the synthesis of covalently stabilized hollow capsules from biodegradable materials using a combination of click chemistry and layer-by-layer (LbL) assembly. The biodegradable polymers poly(L-lysine) (PLL) and poly(L-glutamic acid) (PGA) were modified with alkyne and azide moieties. Linear film buildup was observed for both materials on planar surfaces and colloidal silica templates. A variation of the assembly conditions, such as an increase in the salt concentration and variations in pH, was shown to increase the individual layer thickness by almost 200%. The biodegradable click capsules were analyzed with optical microscopy, scanning electron microscopy (SEM), and atomic force m..View full abstract
Awarded by Swiss National Science Foundation (SNF
We thank A. Postma for SEM images. This work was supported by the Australian Research Council under the Federation Fellowship and Discovery Project schemes. The Swiss National Science Foundation (SNF, PBEZB-118906) is also acknowledged for support.