C1 neurons in the rat rostral ventrolateral medulla differentially express vesicular monoamine transporter 2 in soma and axonal compartments
CP Sevigny, J Bassi, AG Teschemacher, KS Kim, DA Williams, CR Anderson, AM Allen
EUROPEAN JOURNAL OF NEUROSCIENCE | WILEY | Published : 2008
Vesicular monoamine transporter 2 (VMAT2) packages biogenic amines into large dense core and synaptic vesicles for either somatodendritic or synaptic release from neurons of the CNS. Whilst the distribution of VMAT2 has been well characterized in many catecholaminergic cell groups, its localization amongst C1 adrenergic neurons in the medulla has not been examined in detail. Within the rostral ventrolateral medulla (RVLM), C1 neurons are a group of barosensitive, adrenergic neurons. Rostral C1 cells project to the thoracic spinal cord and are considered sympathetic premotor neurons. The majority of caudal C1 cells project rostrally to regions such as the hypothalamus. The present study sough..View full abstract
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We thank Associate Professor S. Kasparov, Department of Physiology, University of Bristol, for his contribution to generation of the lentiviruses and helpful comments on the manuscript. Funding for this project was received from the NHMRC (A. M. A., Project grant: 454432), the ARC (D. A. W., Project ID: DP0770955) and the Dean Robert Winter Trust (ANZ Trustees). C. P. S. is the recipient of a NHMRC Dora Lush Postgraduate Scholarship.