C1 neurons in the rat rostral ventrolateral medulla differentially express vesicular monoamine transporter 2 in soma and axonal compartments

CP Sevigny; J Bassi; AG Teschemacher; KS Kim; DA Williams; CR Anderson; AM Allen

Journal article

C1 neurons in the rat rostral ventrolateral medulla differentially express vesicular monoamine transporter 2 in soma and axonal compartments

CP Sevigny, J Bassi, AG Teschemacher, KS Kim, DA Williams, CR Anderson, AM Allen

European Journal of Neuroscience | WILEY | Published : 2008

DOI: 10.1111/j.1460-9568.2008.06445.x

Abstract

Vesicular monoamine transporter 2 (VMAT2) packages biogenic amines into large dense core and synaptic vesicles for either somatodendritic or synaptic release from neurons of the CNS. Whilst the distribution of VMAT2 has been well characterized in many catecholaminergic cell groups, its localization amongst C1 adrenergic neurons in the medulla has not been examined in detail. Within the rostral ventrolateral medulla (RVLM), C1 neurons are a group of barosensitive, adrenergic neurons. Rostral C1 cells project to the thoracic spinal cord and are considered sympathetic premotor neurons. The majority of caudal C1 cells project rostrally to regions such as the hypothalamus. The present study sough..

View full abstract

University of Melbourne Researchers

Charles Sevigny Author

Jaspreet Bassi Author

David Williams Author

Andrew Allen Author

Related Projects (2)

Interactions between the respiratory and sympathetic nervous systems in high blood pressure.

Hypertension is a common health disorder in all societies and is a major risk factor for the development of life threatening cardiovascular ..

Transduction of neuronal signals by brain macroglial cells: implications for neuronal function

Study of mechanisms regulating brain cell (neuron and glial) communication is essential for understanding of normal brain function and trans..

Grants

Awarded by NHMRC

Awarded by ARC

Awarded by Australian Research Council

Funding Acknowledgements

We thank Associate Professor S. Kasparov, Department of Physiology, University of Bristol, for his contribution to generation of the lentiviruses and helpful comments on the manuscript. Funding for this project was received from the NHMRC (A. M. A., Project grant: 454432), the ARC (D. A. W., Project ID: DP0770955) and the Dean Robert Winter Trust (ANZ Trustees). C. P. S. is the recipient of a NHMRC Dora Lush Postgraduate Scholarship.