Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats
Sarah K McCann, Gregory J Dusting, Carli L Roulston
JOURNAL OF NEUROSCIENCE RESEARCH | WILEY | Published : 2008
Oxidative stress contributes to the progression of brain injury following ischemic stroke and reperfusion. NADPH oxidase is a well-established source of superoxide in vascular disease, but its contribution to tissue injury following ischemic stroke has yet to be fully elucidated. Here we show the spatiotemporal profile of NADPH oxidase subunits Nox2 and Nox4 and concurrent superoxide generation following stroke induced by middle cerebral artery constriction in conscious rats. Nox2 mRNA was progressively up-regulated in both the ipsilateral cortex and the striatum from 6 hr to 7 days poststroke and reperfusion. Nox4 mRNA was also up-regulated transiently in the cortex at 6 hr poststroke but r..View full abstract
Awarded by National Heart Foundation of Australia
Awarded by NHMRC
National Heart Foundation of Australia; Contract grant number G-05M2169; Contract grant sponsor: Cass Foundation Science and Medicine Grant; Contract grant sponsor: Perpetual Trustees; Contract grant sponsor: NHMRC; Contract grant number: 400303 (to G.J.D.).