Journal article

Asymmetry of language activation relates to regional callosal morphology following early cerebral injury

AG Wood, MM Saling, GD Jackson, DC Reutens

EPILEPSY & BEHAVIOR | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2008

Abstract

The anatomical factors underlying reorganization of language representation are yet to be elucidated, although correlations between asymmetric structures and language lateralization have been identified. Previous research has implicated the corpus callosum in the development of language lateralization. This study examined the relationship between callosal morphology and language asymmetry, using letter fluency functional magnetic resonance imaging, in 13 patients with focal epilepsy and 8 healthy controls. Regional callosal thickness was determined without relying on a priori delineation of callosal segments. We predicted that language asymmetry measured by fMRI activation laterality scores ..

View full abstract