Effects of intestinal inflammation on specific subgroups of guinea-pig celiac ganglion neurons
Xiao-xia Dong, Michelle Thacker, Louise Pontell, John B Furness, Kulmira Nurgali
NEUROSCIENCE LETTERS | ELSEVIER IRELAND LTD | Published : 2008
The consequences of inflammation of a short region of the guinea-pig ileum on the properties of neurons in the celiac ganglia were investigated. Inflammation (ileitis) was induced in 5-8 cm of intestine by the intralumenal injection of trinitrobenzene sulfonate, 6-7 days before tissue was taken. Celiac ganglion neurons were investigated using intracellular microelectrodes and the cells were filled with dye from the recording electrode, to determine their morphologies. Tonic and phasic neurons were identified. In ganglia from normal guinea-pigs and from guinea-pigs with ileitis, cell bodies of tonic neurons were larger and their dendrites were longer and more numerous than those of phasic neu..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
This work was supported by project grant 400020 from the National Health and Medical Research Council (NHMRC) of Australia. Dr. Nurgali is supported by a NHMRC Peter Doherty (Biomedical) Fellowship. We thank Drs. Daniel Poole and Karina Needham for their insightful comments on the manuscript.