Age of transfused red cells and early outcomes after cardiac surgery

Abstract

BACKGROUND: Red blood cells (RBC) undergo many changes during storage. Such changes are associated with reduced oxygen-carrying capacity and transfusion-related inflammatory reactions. The clinical significance of these changes in the cardiac surgical setting is unclear. This observational cohort study investigates the association between age of transfused RBC and early outcomes after cardiac surgery. METHODS: The cardiac surgery database at St. Vincent's Hospital Melbourne was cross-referenced with the Blood Transfusion Services database. In all, 670 consecutive patients who had nonemergency coronary artery bypass grafting or aortic valve replacement, or both, between June 2001 and June 200..