Journal article

Dosing Quetiapine in Drug-Naive First-Episode Psychosis: A Controlled, Double-Blind, Randomized, Single-Center Study Investigating Efficacy, Tolerability, and Safety of 200 mg/day vs. 400 mg/day of Quetiapine Fumarate in 141 Patients Aged 15 to 25 Years

Gregor E Berger, Tina-Marie Proffitt, Mirabel McConchie, Melissa Kerr, Connie Markulev, Hok Pan Yuen, Colin O'Donnell, Dan Lubman, Andrea Polari, Stephen Wood, G Paul Amminger, Patrick D McGorry

JOURNAL OF CLINICAL PSYCHIATRY | PHYSICIANS POSTGRADUATE PRESS | Published : 2008

Abstract

OBJECTIVE: To assess dosing, efficacy, and tolerability of quetiapine fumarate in drug-naive first-episode psychosis. METHOD: We present a prospective, randomized, controlled, single-center, double-blind, fixed-dose, 4-week comparison study of 200 mg/day versus 400 mg/day of quetiapine in 141 drug-naive acutely ill first-episode psychosis patients (diagnosed according to DSM-IV) aged 15 to 25 years. The double-blind 4-week trial (Part 1) was followed by a single-blind, naturalistic, flexible-dose 8-week period (Part 2). The main outcome measures were symptomatic change, functioning, and tolerability. Data were collected from July 2003 until January 2006. RESULTS: The estimated time trends of..

View full abstract