The prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian antenatal population
Joanne M Said, Shaun P Brennecke, Eric K Moses, Susan P Walker, Paul T Monagle, Janine Campbell, Valerie J Bryant, Anthony J Borg, John R Higgins
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY | WILEY | Published : 2008
AIM: Inherited thrombophilic polymorphisms have been linked to pregnancy-related thromboembolism and other adverse pregnancy outcomes. As there are limited data on the prevalence of these polymorphisms in Australian populations, we aimed to assess this in an antenatal population. METHODS: Healthy nulliparous women (n = 2031) were recruited to this study. The women had no past or family history of venous thromboembolism. Women were excluded if they or a family member was known to be a carrier of any thrombophilic marker. Genotyping from venous blood for the factor V Leiden, prothrombin 20210A, MTHFR 677 and 1298 and thrombomodulin C1418T polymorphisms was undertaken. RESULTS: Key findings wer..View full abstract
We gratefully acknowledge the work of the Clinical Research Midwives, Pathology Collection staff and Laboratory specimen handlers at both The Royal Women's Hospital and the Mercy Hospital for Women for their invaluable assistance in recruitment of subjects and sample collection. This project has been supported by grants from the Kings Jubilee Fund ( City of Melbourne), Hospital X and The University of Melbourne (Australian Postgraduate Award and Felix Meyer Scholarship).