Journal article

PEDF as an Emerging Therapeutic Candidate for Osteosarcoma

Crispin R Dass, Eugene TH Ek, Peter FM Choong

CURRENT CANCER DRUG TARGETS | BENTHAM SCIENCE PUBL LTD | Published : 2008

Abstract

Osteosarcoma (OS) is a disease that afflicts teenagers and adolescents in the prime of their lives. In spite of surgery and therapies currently used, there is a 1/3 chance of relapse. As for other cancers, current research is largely devoted to elucidating the molecular basis of the disease, with the anticipation that such research will lead to discovery and development of biological therapies. The major advantage of utilising such therapy is the relative lack of toxicity to normal tissues. One such enterprising candidate molecule, pigment epithelium-derived factor (PEDF), has recently been implicated to be involved in control of OS in orthotopic spontaneously metastasising models of the dis..

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