Review article: the psychoneuroimmunology of irritable bowel syndrome - an exploration of interactions between psychological, neurological and immunological observations
N Arebi, S Gurmany, D Bullas, A Hobson, A Stagg, M Kamm
ALIMENTARY PHARMACOLOGY & THERAPEUTICS | WILEY | Published : 2008
BACKGROUND: The pathogenesis of irritable bowel syndrome (IBS) is founded on interactive mechanisms. Disentangling these processes is a prerequisite for the development of effective drug therapy. AIM: To identify the interaction between the various factors implicated in IBS. METHODS: Articles pertaining to IBS pathogenesis focusing on psychoneuroimmunology were identified using following search terms: IBS, animal models, microbiota, probiotics, immunology, visceral hypersensitivity, imaging, psychology and visceral pain. RESULTS: Cerebral imaging using MRI and proton emission tomography scanning has revealed differential regional cerebral activation, whereas stimuli induced activation has be..View full abstract
Declaration of personal and funding interests: Or Arebi has served as a speaker and advisory board member for Schering Plough; Er Hobson is an employee of GSK; Dr Bullus has received research funding from GSK-Imperial aADI Grant.