Journal article

Rhabdoid tumour: a malignancy of early childhood with variable primary site, histology and clinical behaviour

Xiangru Wu, Vinod Dagar, Elizabeth Algar, Andrea Muscat, Pratiti Bandopadhayay, David Ashley, Chung Wo Chow

PATHOLOGY | ELSEVIER SCIENCE BV | Published : 2008

Abstract

AIMS: To correlate the immunostaining for INI1 protein and mutations in INI1 gene in possible rhabdoid tumours (RT) and atypical teratoid/rhabdoid tumours (AT/RT) seen at the Royal Children's Hospital in the last 10 years, and to study the clinicopathological features of those patients with negative nuclear staining. METHODS: Twenty tumours showing suggestive histological and/or immunohistochemical features of RT and AT/RT were selected. Immunohistochemistry for INI1 and molecular investigations for INI1 mutations were performed. The clinical features, histology and immunohistochemistry in those patients with negative nuclear staining were studied. RESULTS: In seven tumours the nuclei staine..

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