Journal article

Prevalence of HSV-2 antibody in a Melbourne antenatal population attending a tertiary obstetric hospital

Joseph John Sasadeusz, Julie Elizabeth Silvers, Helen Elizabeth Kent, Wayne Devenish, Jane Hocking, Suzanne Marie Garland

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY | WILEY-BLACKWELL | Published : 2008

Abstract

OBJECTIVE: To determine the herpes simplex virus 2 (HSV-2) seroprevalence rate in a Melbourne antenatal cohort. DESIGN: Prospective collection of serum and questionnaires in 1371 women attending an outpatient antenatal clinic. SETTING: A tertiary obstetric hospital in metropolitan Melbourne. PARTICIPANTS: Women aged 18 years or older attending an antenatal clinic appointment. MAIN OUTCOME MEASURE: Seroprevalence rate of HSV-2 using an ELISA-based- type-specific serological assay. RESULTS: The overall HSV-2 seroprevalence rate in women was 13.6%. Only 0.4% of assays were equivocal and required confirmation by Western blot analysis. By multivariate analysis, HSV-2 seroprevalence was found to b..

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