Journal article

Correction of copper metabolism is not sustained long term in Wilson's disease mice post bone marrow transplantation

Nicole E Buck, Daphne MY Cheah, Ngaire J Elwood, Paul FA Wright, Katrina J Allen

HEPATOLOGY INTERNATIONAL | SPRINGER | Published : 2008

Abstract

PURPOSE: Alternative cell sources have been sought for the treatment of liver diseases, since liver cells are in short supply for cell transplantation. Although bone marrow-derived cells have been investigated as an alternative cell source, few studies have demonstrated long-term disease correction. Here we examined bone marrow stem cell transplantation into the toxic milk (tx) mouse model for Wilson's disease, a mild liver disease characterized by hepatic copper accumulation. The aim of this study was to determine whether bone marrow cells engrafted in the liver could sustain correction of abnormal copper metabolism in the tx mouse. METHODS: Bone marrow cells were isolated from congenic nor..

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