Insights into mechanisms of intestinal segmentation in guinea pigs: a combined computational modeling and in vitro study
Jordan D Chambers, Joel C Bornstein, Evan A Thomas
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2008
Segmentation in the guinea pig small intestine consists of a number of discrete motor patterns including rhythmic stationary contractions that occur episodically at specific locations along the intestine. The enteric nervous system regulates segmentation, but the exact circuit is unknown. Using simple computer models, we investigated possible circuits. Our computational model simulated the mean neuron firing rate in the feedforward ascending and descending reflex pathways. A stimulus-evoked pacemaker was located in the afferent pathway or in a feedforward pathway. Output of the feedforward pathways was fed into a simple model to determine the response of the muscle. Predictions were verified..View full abstract
Awarded by Australia National Health and Medical Research Council (NHMRC)
This study was supported by Australia National Health and Medical Research Council (NHMRC) Grant 400053. E. Thomas was supported by an NHMRC Peter Doherty fellowship. J. Chambers was supported by a Melbourne Research Scholarship.