Connective tissue disorder - a new subgroup of boys with slow transit constipation?
Daniel J Reilly, Janet W Chase, John M Hutson, Melanie C Clarke, Susie Gibb, Barry Stillman, Bridget R Southwell
JOURNAL OF PEDIATRIC SURGERY | W B SAUNDERS CO-ELSEVIER INC | Published : 2008
PURPOSE: Slow transit constipation (STC) is a form of chronic constipation, with delayed colonic passage of stool. Possible etiologies include reduced neurotransmitter levels, reduced interstitial cells of Cajal density, or a disorder of connective tissue (CT) synthesis. A common CT disorder is generalized joint hypermobility (GJH). This study aimed to investigate whether there was a greater prevalence of GJH among patients with STC than controls. METHODS: Children (aged 7-17) diagnosed with STC by radio/nuclear transit study were recruited from outpatient clinics. Controls (no history of constipation) were recruited from outpatient clinics and a scout jamboree. Hypermobility was assessed us..View full abstract