Risk Factors Related to Inflammation and Endothelial Dysfunction in the DCCT/EDIC Cohort and Their Relationship With Nephropathy and Macrovascular Complications
Maria F Lopes-Virella, Rickey E Carter, Gregory E Gilbert, Richard L Klein, Miran Jaffa, Alicia J Jenkins, Timothy J Lyons, W Timothy Garvey, Gabriel Virella
DIABETES CARE | AMER DIABETES ASSOC | Published : 2008
OBJECTIVE: Because endothelial cell dysfunction and inflammation are key contributors to the development of complications in type 1 diabetes, we studied risk factors related to endothelial dysfunction and inflammation (C-reactive protein and fibrinogen, soluble vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin, and fibrinolytic markers) in a subgroup of patients from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) study cohort. RESEARCH DESIGN AND METHODS: We determined which of these risk factors or clusters thereof are associated with the presence of and subsequent development of nephropat..View full abstract
Awarded by National Institutes of Health and Juvenile Diabetes Research Foundation
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
This research was supported by funding of the Merit Review Program of the Department of Veterans Affairs and by joint funding of the National Institutes of Health and Juvenile Diabetes Research Foundation (PO1 HL55782). The DCCT/EDIC Research Group is sponsored through research contracts from the National Institute of Diabetes, Endocrinology and Metabolic Diseases of the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institutes of Health.The technical assistance of Charlyne Chassereau, Andrea Semler, and Karma Moller and efforts of stud), coordinators jenny Smith, Leslie Nicholson, Marlene Brabham, and Erica Hood are gratefully acknowledged. Finally, the authors are grateful to the patients in the DCCT/EDIC cohort for their long-term participation in this important trial.