Role of Kruppel-like factor 6 in transforming growth factor-beta 1-induced epithelial-mesenchymal transition of proximal tubule cells
John Holian, Weier Qi, Darren J Kelly, Yuan Zhang, Ellein Mreich, Carol A Pollock, Xin-Ming Chen
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2008
Krüppel-like factor 6 (KLF6) is a DNA-binding protein containing a triple zinc-fingered motif and plays a key role in the regulation of cell proliferation, differentiation, and development. More recently it has been implicated in hepatic fibrosis via its binding to the transforming growth factor (TGF)-beta control element. In the kidney, epithelial-mesenchymal transition (EMT) is a major contributor to the pathogenesis of renal fibrosis, with TGF-beta1 being a key mediator of EMT. The present study aimed to determine the role of KLF6 and TGF-beta1 in EMT in proximal tubule cells. To determine the relevance in clinical disease, KLF6 was measured in kidneys of streptozotocin-induced diabetic R..View full abstract
These studies were supported by the National Health and Medical Research Council of Australia (NHMRC). W. Qi is supported by an NHMRC Peter Doherty Fellowship.