Journal article

Myocardial gene expression associated with genetic cardiac hypertrophy in the absence of hypertension

Jeremy P Dwyer, Matthew E Ritchie, Gordon K Smyth, Stephen B Harrap, Lea MD Delbridge, Andrea A Domenighetti, Robert Di Nicolantonio

HYPERTENSION RESEARCH | NATURE PUBLISHING GROUP | Published : 2008

Abstract

The hypertrophic heart rat (HHR) was derived from the spontaneously hypertensive rat of the Okamoto strain and develops cardiac hypertrophy in the absence of hypertension. The genetic basis of this hypertrophy is unknown. Therefore, we compared gene expression profiles in the left ventricular myocardium of young (8-10 weeks of age) and old (38-50 weeks) HHR with rats from an age-matched control strain, the normal heart rat (NHR). cDNA microarrays (National Institute of Aging [NIA], 15,247 clones) were used to evaluate gene expression in cardiac-derived Cy3 and Cy5 labeled cDNA. M values (log2[Cy5/Cy3]) were obtained and significant differential expression was identified using an empirical Ba..

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